Association between Dietary Patterns and Atopic Dermatitis in Relation to GSTM1 and GSTT1 Polymorphisms in Young Children.

ABSTRACT: Previous research suggests the association of glutathione S-transferase (GST) gene polymorphisms or diet, but no interactions between these factors in atopic dermatitis (AD). We conducted a community-based case-control study including 194 AD and 244 matched non-AD preschoolers. Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) present/null genotypes were evaluated uisng a multiplex PCR method. We measured dietary intakes by a validated food frequency questionnaire and constructed three dietary patterns such as "traditional healthy", "animal foods", and "sweets" diets. In stratified analyses by GST genotypes, the "traditional healthy" diet and reduced AD showed association only in the GSTM1-present group (odd ratio (OR) 0.31, 95% confidence interval (CI) 0.13-0.75). A similar pattern of t

SUBMITTER: Chung J 

PROVIDER: S-EPMC4663601 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature