Association between the TLR2 Arg753Gln polymorphism and the risk of sepsis: a meta-analysis.

ABSTRACT:

Introduction

Recently, researchers in a number of studies have explored the association between the Toll-like receptor 2 (TLR2) Arg753Gln polymorphism and sepsis risk. However, the results were conflicting. In this meta-analysis, we aimed to confirm the effect of the TLR2 Arg753Gln polymorphism on sepsis risk.

Methods

Relevant records up to 1 June 2015 were retrieved from the PubMed, Embase, and Web of Knowledge databases. The odds ratios with their corresponding 95 % confidence intervals were used to assess the association between the TLR2 Arg753Gln polymorphism and sepsis risk. The selection of a fixed or random effects model was made according to a heterogeneity test in total and subgroup analyses. Sensitivity analysis and publication bias test were performed to ensure th

SUBMITTER: Gao JW 

PROVIDER: S-EPMC4663740 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature