Phenotypic differentiation of gastrointestinal microbes is reflected in their encoded metabolic repertoires.

ABSTRACT:

Background

The human gastrointestinal tract harbors a diverse microbial community, in which metabolic phenotypes play important roles for the human host. Recent developments in meta-omics attempt to unravel metabolic roles of microbes by linking genotypic and phenotypic characteristics. This connection, however, still remains poorly understood with respect to its evolutionary and ecological context.

Results

We generated automatically refined draft genome-scale metabolic models of 301 representative intestinal microbes in silico. We applied a combination of unsupervised machine-learning and systems biology techniques to study individual and global differences in genomic content and inferred metabolic capabilities. Based on the global metabolic differences, we found that energ

SUBMITTER: Bauer E 

PROVIDER: S-EPMC4663747 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature