Effect of pneumococcal conjugate vaccine on pneumococcal meningitis.

ABSTRACT:

Background

Invasive pneumococcal disease declined among children and adults after the introduction of the pediatric heptavalent pneumococcal conjugate vaccine (PCV7) in 2000, but its effect on pneumococcal meningitis is unclear.

Methods

We examined trends in pneumococcal meningitis from 1998 through 2005 using active, population-based surveillance data from eight sites in the United States. Isolates were grouped into PCV7 serotypes (4, 6B, 9V, 14, 18C, 19F, and 23F), PCV7-related serotypes (6A, 9A, 9L, 9N, 18A, 18B, 18F, 19B, 19C, 23A, and 23B), and non-PCV7 serotypes (all others). Changes in the incidence of pneumococcal meningitis were assessed against baseline values from 1998-1999.

Results

We identified 1379 cases of pneumococcal meningitis. The incidence declined

SUBMITTER: Hsu HE 

PROVIDER: S-EPMC4663990 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature