Obesity and excess weight in early adulthood and high risks of arsenic-related cancer in later life.

ABSTRACT:

Background

Elevated body mass index (BMI) is a risk factor for cardiovascular disease, diabetes, cancer, and other diseases. Inflammation or oxidative stress induced by high BMI may explain some of these effects. Millions of people drink arsenic-contaminated water worldwide, and ingested arsenic has also been associated with inflammation, oxidative stress, and cancer.

Objectives

To assess the unique situation of people living in northern Chile exposed to high arsenic concentrations in drinking water and investigate interactions between arsenic and BMI, and associations with lung and bladder cancer risks.

Methods

Information on self-reported body mass index (BMI) at various life stages, smoking, diet, and lifetime arsenic exposure was collected from 532 cancer cases an

SUBMITTER: Steinmaus C 

PROVIDER: S-EPMC4664040 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature