Functional Module Analysis for Gene Coexpression Networks with Network Integration.

ABSTRACT: Network has been a general tool for studying the complex interactions between different genes, proteins, and other small molecules. Module as a fundamental property of many biological networks has been widely studied and many computational methods have been proposed to identify the modules in an individual network. However, in many cases, a single network is insufficient for module analysis due to the noise in the data or the tuning of parameters when building the biological network. The availability of a large amount of biological networks makes network integration study possible. By integrating such networks, more informative modules for some specific disease can be derived from the networks constructed from different tissues, and consistent factors for different diseases can be inferred

SUBMITTER: Zhang S 

PROVIDER: S-EPMC4664071 | biostudies-literature | 2015 Sep-Oct

REPOSITORIES: biostudies-literature