Association of Higher Defensin β-4 Genomic Copy Numbers with Behcet's Disease in Iraqi Patients.

ABSTRACT:

Objectives

Behçet's disease (BD) is an immune-mediated small vessel systemic vasculitis. Human β-defensins are antimicrobial peptides associated with many inflammatory diseases and are encoded by the β-defensin family of multiple-copy genes. However, their role in BD necessitates further investigation. The aim of the present study was to investigate the possible association of BD in its various clinical forms with defensin β-4 (DEFB4) genomic copy numbers.

Methods

This case-control study was conducted from January to September 2011 and included 50 control subjects and 27 unrelated Iraqi BD patients registered at Baghdad Teaching Hospital, Bagdad, Iraq. Copy numbers of the DEFB4 gene were determined using the comparative cycle threshold method by duplex real-time polymerase c

SUBMITTER: Hameed AF 

PROVIDER: S-EPMC4664093 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature