Differences in the burden of psychiatric comorbidity in MS vs the general population.

ABSTRACT:

Objective

We aimed to compare the incidence and prevalence of psychiatric comorbidity in the multiple sclerosis (MS) population and in controls matched for age, sex, and geographic area.

Methods

Using population-based administrative health data from 4 Canadian provinces, we identified 2 cohorts: 44,452 persons with MS and 220,849 controls matched for age, sex, and geographic area. We applied validated case definitions to estimate the incidence and prevalence of depression, anxiety, bipolar disorder, and schizophrenia from 1995 to 2005. We pooled the results across provinces using meta-analyses.

Results

Of the MS cases, 31,757 (71.3%) were women with a mean (SD) age at the index date of 43.8 (13.7) years. In 2005, the annual incidence of depression per 100,000 persons

SUBMITTER: Marrie RA 

PROVIDER: S-EPMC4664123 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature