Sensitivity to acute cerebral ischemic injury in migraineurs: A retrospective case-control study.

ABSTRACT:

Objective

Migraine, particularly with aura, is a risk factor for ischemic stroke. Recent data in migraine mutant mice suggest that cerebral hyperexcitability associated with migraine accelerates recruitment of ischemic penumbra into the core, resulting in faster infarct growth compared with wild type. We hypothesized that individuals with a history of migraine are more likely to exhibit increased recruitment of ischemic tissue into the infarct in acute stroke.

Methods

In this retrospective case-control study, we identified participants with reliably documented migraine history, measured lesion volumes on diffusion-weighted and perfusion-weighted MRI obtained within 72 hours of symptom onset, calculated the proportion of ischemic tissue on perfusion-weighted imaging (PWI) hyp

SUBMITTER: Mawet J 

PROVIDER: S-EPMC4664124 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature