Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons.

ABSTRACT:

Objective

We tested the hypothesis that cerebral amyloid angiopathy (CAA) is related to Alzheimer disease (AD) dementia and decline in multiple cognitive systems in old age, independent of AD plaque and tangle pathology and other common age-related neuropathologies.

Methods

Participants (n = 1,113) came from 2 longitudinal clinical-pathologic studies of aging, the Rush Memory and Aging Project and the Religious Orders Study. All underwent annual clinical evaluations including detailed cognitive testing for a mean of 7.1 years before death. Clinical diagnoses of AD were established after reviewing all clinical data, blinded to neuropathologic information. Neuropathologic examinations provided measures of CAA, AD pathology, macroscopic infarcts, microinfarcts, and neocortical

SUBMITTER: Boyle PA 

PROVIDER: S-EPMC4664125 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature