Identifying post-menopausal women at elevated risk for epithelial ovarian cancer.

ABSTRACT:

Objective

We developed and validated a hybrid risk classifier combining serum markers and epidemiologic risk factors to identify post-menopausal women at elevated risk for invasive fallopian tube, primary peritoneal, and ovarian epithelial carcinoma.

Methods

To select epidemiologic risk factors for use in the classifier, Cox proportional hazards analyses were conducted using 74,786 Women's Health Initiative (WHI) Observational Study (OS) participants. To construct a combination classifier, 210 WHI OS cases and 536 matched controls with serum marker measurements were analyzed; validation employed 143 cases and 725 matched controls from the WHI Clinical Trial (CT) with similar data.

Results

Analyses identified a combination risk classifier composed of two elevated-risk

SUBMITTER: Urban N 

PROVIDER: S-EPMC4664187 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature