Synthesis and immunological studies of linear oligosaccharides of β-glucan as antigens for antifungal vaccine development.

ABSTRACT: Antifungal vaccines have recently engendered considerable excitement for counteracting the resurgence of fungal infections. In this context, β-glucan, which is abundantly expressed on all fungal cell surfaces, functionally necessary for fungi, and immunologically active, is an attractive target antigen. Aiming at the development of effective antifungal vaccines based on β-glucan, a series of its oligosaccharide derivatives was designed, synthesized, and coupled with a carrier protein, keyhole limpet hemocyanin (KLH), to form new semisynthetic glycoconjugate vaccines. In this article, a convergent and effective synthetic strategy using preactivation-based iterative glycosylation was developed for the designed oligosaccharides. The strategy can be widely useful for rapid construction of larg

SUBMITTER: Liao G 

PROVIDER: S-EPMC4664189 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature