Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.

ABSTRACT: Previous genome-wide association studies (GWAS) of HIV-1-infected populations have been underpowered to detect common variants with moderate impact on disease outcome and have not assessed the phenotypic variance explained by genome-wide additive effects. By combining the majority of available genome-wide genotyping data in HIV-infected populations, we tested for association between ∼8 million variants and viral load (HIV RNA copies per milliliter of plasma) in 6,315 individuals of European ancestry. The strongest signal of association was observed in the HLA class I region that was fully explained by independent effects mapping to five variable amino acid positions in the peptide binding grooves of the HLA-B and HLA-A proteins. We observed a second genome-wide significant association sign

SUBMITTER: McLaren PJ 

PROVIDER: S-EPMC4664299 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature