Induction of interferon-λ contributes to TLR3 and RIG-I activation-mediated inhibition of herpes simplex virus type 2 replication in human cervical epithelial cells.

ABSTRACT:

Study hypothesis

Is it possible to immunologically activate human cervical epithelial cells to produce antiviral factors that inhibit herpes simplex virus type 2 (HSV-2) replication?

Study finding

Our results indicate that human cervical epithelial cells possess a functional TLR3/RIG-I signaling system, the activation of which can mount an Interferon-λ (IFN-λ)-mediated anti-HSV-2 response.

What is known already

There is limited information about the role of cervical epithelial cells in genital innate immunity against HSV-2 infection.

Study design, samples/materials, methods

We examined the expression of toll-like receptors (TLRs) and retinoic acid-inducible I (RIG-I) in End1/E6E7 cells by real-time PCR. The IFN-λ induced by TLR3 and RIG-I activation of End1/E6E

SUBMITTER: Zhou L 

PROVIDER: S-EPMC4664393 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature