Genome-wide analysis of DNA methylation associated with HIV infection based on a pair of monozygotic twins.

ABSTRACT: Alteration of DNA methylation in mammalian cells could be elicited by many factors, including viral infections [1]. HIV has shown the ability to interact with host cellular factors to change the methylation status of some genes [2], [3], [4]. However, the change of the DNA methylation associated with HIV infection based on the whole genome has not been well illustrated. In this study, a unique pair of monozygotic twins was recruited: one of the twins was infected with HIV without further anti-retroviral therapy while the other one was healthy, which could be considered as a relatively ideal model for profiling the alterations of DNA methylation associated with HIV infection. Therefore, using methylated DNA immunoprecipitation-microarray method (MeDIP-microarray), we found the increased DNA

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4664672 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature