Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation.

ABSTRACT: Adult stem cells (ASCs) reside in specific niches in a quiescent state in adult mammals. Upon specific cues they become activated and respond by self-renewing and differentiating into newly generated specialised cells that ensure appropriate tissue fitness. ASC quiescence also serves as a tumour suppression mechanism by hampering cellular transformation and expansion (White AC et al., 2014). Some genes restricted to early embryonic development and adult stem cell niches are often potent modulators of stem cell quiescence, and derailed expression of these is commonly associated to cancer (Vervoort SJ et al., 2013). Among them, it has been shown that recommissioned Sox4 expression facilitates proliferation, survival and migration of malignant cells. By generating a conditional Knockout mouse

SUBMITTER: Foronda M 

PROVIDER: S-EPMC4664675 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature