Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model.

ABSTRACT: Primary afferent collateral sprouting is a process whereby non-injured primary afferent neurons respond to some stimulus and extend new branches from existing axons. Neurons of both the central and peripheral nervous systems undergo this process, which contributes to both adaptive and maladaptive plasticity (e.g., [1], [2], [3], [4], [5], [6], [7], [8], [9]). In the model used here (the "spared dermatome" model), the intact sensory neurons respond to the denervation of adjacent areas of skin by sprouting new axon branches into that adjacent denervated territory. Investigations of gene expression changes associated with collateral sprouting can provide a better understanding of the molecular mechanisms controlling this process. Consequently, it can be used to develop treatments to promote f

SUBMITTER: Harrison BJ 

PROVIDER: S-EPMC4664766 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature