Genome wide transcription profiling of the effects of overexpression of Spc1 and its kinase dead mutant in Schizosaccharomyces pombe.

ABSTRACT: The Mitogen Activated Protein Kinase Spc1 (p38 homolog) is a major player in stress responses of the unicellular fission yeast Schizosaccharomyces pombe. This pathway is therefore also known as the SAPK or Stress Activated Protein Kinase pathway. Spc1 is a known activator of transcription factors that control gene expression in response to extracellular stimuli and is also known to interact with the translation machinery [1], [2], [3], [4], [5], [6], [7], [8]. Spc1 has also been implicated in cell cycle regulation and meiosis in S. pombe[1], [2], [9], [10]. Given its documented role in modulating gene expression, we performed a microarray based identification of genes whose expression in unperturbed cells (absence of stress stimuli) is dependent on Spc1. For this we overexpressed Spc1 in S

SUBMITTER: Paul M 

PROVIDER: S-EPMC4664770 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature