Alzheimer's Disease: Exploring the Role of Inflammation and Implications for Treatment.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by both structural abnormalities and inflammation in the brain. While recent research has chiefly focused on the structural changes involved in AD, understanding the pathophysiology and associated inflammation of the AD brain helps to elucidate potential therapeutic and preventative options. By exploring the data supporting an inflammatory etiology of AD, we present a case for the use of existing evidence-based treatments addressing inflammation as promising options for treating and preventing AD. We present data demonstrating tumor necrosis factor alpha association with the inflammation of AD. We also discuss data supporting TNF alpha associated inflammation in traumatic brain injury, stroke, and spinal disc associated

SUBMITTER: McCaulley ME 

PROVIDER: S-EPMC4664815 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature