Multilayered Graphene Nano-Film for Controlled Protein Delivery by Desired Electro-Stimuli.

ABSTRACT: Recent research has highlighted the potential use of "smart" films, such as graphene sheets, that would allow for the controlled release of a variety of therapeutic drugs. Taking full advantage of these versatile conducting sheets, we investigated the novel concept of applying graphene oxide (GO) and reduced graphene oxide (rGO) materials as both barrier and conducting layers that afford controlled entrapment and release of any molecules of interest. We fabricated multilayered nanofilm architectures using a hydrolytically degradable cationic poly(β-amino ester) (PAE), a model protein antigen, ovalbumin (OVA) as a building block along with the GO and rGO. We successfully showed that these multilayer films are capable of blocking the initial burst release of OVA, and they can be triggered to

SUBMITTER: Choi M 

PROVIDER: S-EPMC4664934 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature