A probabilistic method for testing and estimating selection differences between populations.

ABSTRACT: Human populations around the world encounter various environmental challenges and, consequently, develop genetic adaptations to different selection forces. Identifying the differences in natural selection between populations is critical for understanding the roles of specific genetic variants in evolutionary adaptation. Although numerous methods have been developed to detect genetic loci under recent directional selection, a probabilistic solution for testing and quantifying selection differences between populations is lacking. Here we report the development of a probabilistic method for testing and estimating selection differences between populations. By use of a probabilistic model of genetic drift and selection, we showed that logarithm odds ratios of allele frequencies provide estimate

SUBMITTER: He Y 

PROVIDER: S-EPMC4665011 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature