Pulmonary Delivery of siRNA via Polymeric Vectors as Therapies of Asthma.

ABSTRACT: Asthma is a chronic inflammatory disease. Despite the fact that current therapies, such as the combination of inhaled corticosteroids and β2-agonists, can control the symptoms of asthma in most patients, there is still an urgent need for an alternative anti-inflammatory therapy for patients who suffer from severe asthma but lack acceptable response to conventional therapies. Many molecular factors are involved in the inflammatory process in asthma, and thus blocking the function of these factors could efficiently alleviate airway inflammation. RNA interference (RNAi) is often thought to be the answer in the search for more efficient and biocompatible treatments. However, difficulties of efficient delivery of small interference RNA (siRNA), the key factor in RNAi, to target cells and tissue

SUBMITTER: Xie Y 

PROVIDER: S-EPMC4665213 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature