Physalis angulata induces in vitro differentiation of murine bone marrow cells into macrophages.

ABSTRACT:

Background

The bone marrow is a hematopoietic tissue that, in the presence of cytokines and growth factors, generates all of the circulating blood cells. These cells are important for protecting the organism against pathogens and for establishing an effective immune response. Previous studies have shown immunomodulatory effects of different products isolated from plant extracts. This study aimed to evaluate the immunomodulatory properties of aqueous Physalis angulata (AEPa) extract on the differentiation of bone marrow cells.

Results

Increased cellular area, higher spreading ability and several cytoplasmatic projections were observed in the treated cells, using optical microscopy, suggesting cell differentiation. Furthermore, AEPa did not promote the proliferation of lymphoc

SUBMITTER: da Silva BJ 

PROVIDER: S-EPMC4665300 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature