Biomarker Profiles in Asthma With High vs Low Airway Reversibility and Poor Disease Control.

ABSTRACT:

Background

High bronchodilator reversibility in adult asthma is associated with distinct clinical characteristics. This analysis compares lung function, biomarker profiles, and disease control in patients with high reversibility (HR) and low reversibility (LR) asthma.

Methods

A retrospective analysis was performed with data from two completed clinical trials of similar design. Patients were divided into HR and LR subgroups based on their response to bronchodilators (HR = ΔFEV1 postbronchodilator ≥ 20%). Blood eosinophil count, serum IgE level, and fraction of exhaled nitric oxide concentration, biomarkers commonly used to stratify patients into T-helper (Th)-2-high vs Th2-low phenotypes, were measured in patients with not well controlled (1.5 ≤ Asthma Control Questionnaire [

SUBMITTER: Busse WW 

PROVIDER: S-EPMC4665740 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature