Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.

ABSTRACT: Conditions such as muscular dystrophies (MDs) that affect both cardiac and skeletal muscles would benefit from therapeutic strategies that enable regeneration of both of these striated muscle types. Protocols have been developed to promote induced pluripotent stem cells (iPSCs) to differentiate toward cardiac or skeletal muscle; however, there are currently no strategies to simultaneously target both muscle types. Tissues exhibit specific epigenetic alterations; therefore, source-related lineage biases have the potential to improve iPSC-driven multilineage differentiation. Here, we determined that differential myogenic propensity influences the commitment of isogenic iPSCs and a specifically isolated pool of mesodermal iPSC-derived progenitors (MiPs) toward the striated muscle lineages. Di

SUBMITTER: Quattrocelli M 

PROVIDER: S-EPMC4665797 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature