ERCC2 polymorphisms and radiation-induced adverse effects on normal tissue: systematic review with meta-analysis and trial sequential analysis.

ABSTRACT:

Background

The relationship between ERCC2 polymorphisms and the risk of radiotoxicity remains inconclusive. The aim of our study is to systematically evaluate the association between ERCC2 polymorphisms and the risk of radiotoxicity.

Methods

Publications were identified through a search of the PubMed and Web of Science databases up to August 15, 2015. The pooled odds ratios (ORs) with corresponding 95 % confidence intervals (CIs) were calculated to evaluate the association between ERCC2 polymorphisms and radiotoxicity. Trial sequential analysis (TSA) and power calculation were performed to evaluate the type 1 and type 2 errors.

Results

Eleven studies involving 2584 patients were ultimately included in this meta-analysis. Conventional meta-analysis identified a signifi

SUBMITTER: Song YZ 

PROVIDER: S-EPMC4665885 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature