Lack of integrase inhibitors associated resistance mutations among HIV-1C isolates.

ABSTRACT:

Background

Although biochemical analysis of HIV-1 integrase enzyme suggested the use of integrase inhibitors (INIs) against HIV-1C, different viral subtypes may favor different mutational pathways potentially leading to varying levels of drug resistance. Thus, the aim of this study was to search for the occurrence and natural evolution of integrase polymorphisms and/or resistance mutations in HIV-1C Ethiopian clinical isolates prior to the introduction of INIs.

Methods

Plasma samples from chronically infected drug naïve patients (N = 45), of whom the PR and RT sequence was determined previously, were used to generate population based sequences of HIV-1 integrase. HIV-1 subtype was determined using the REGA HIV-1 subtyping tool. Resistance mutations were interpreted according

SUBMITTER: Mulu A 

PROVIDER: S-EPMC4665939 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature