Low serum ficolin-3 levels are associated with severity and poor outcome in traumatic brain injury.

ABSTRACT:

Background

Ficolin-mediated activation of the lectin pathway of complement contributes to the complement-independent inflammatory processes of traumatic brain injury. Lower serum ficolin-3 levels have been demonstrated to be highly associated with unfavorable outcome after ischemic stroke. This prospective observatory study was designed to investigate the relationships between serum ficolin-3 levels and injury severity and clinical outcomes after severe traumatic brain injury.

Methods

Serum ficolin-3 levels of 128 patients and 128 healthy controls were measured by sandwich immunoassays. An unfavorable outcome was defined as Glasgow Outcome Scale score of 1-3. Study endpoints included mortality at 1 week and 6 months and unfavorable outcome at 6 months after head trauma. Inju

SUBMITTER: Pan JW 

PROVIDER: S-EPMC4666053 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature