Bounding the per-protocol effect in randomized trials: an application to colorectal cancer screening.

ABSTRACT:

Background

The per-protocol effect is the effect that would have been observed in a randomized trial had everybody followed the protocol. Though obtaining a valid point estimate for the per-protocol effect requires assumptions that are unverifiable and often implausible, lower and upper bounds for the per-protocol effect may be estimated under more plausible assumptions. Strategies for obtaining bounds, known as "partial identification" methods, are especially promising in randomized trials.

Results

We estimated bounds for the per-protocol effect of colorectal cancer screening in the Norwegian Colorectal Cancer Prevention trial, a randomized trial of one-time sigmoidoscopy screening in 98,792 men and women aged 50-64 years. The screening was not available to the control arm,

SUBMITTER: Swanson SA 

PROVIDER: S-EPMC4666083 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature