Alteration of actin dependent signaling pathways associated with membrane microdomains in hyperlipidemia.

ABSTRACT:

Background

Membrane microdomains represent dynamic membrane nano-assemblies enriched in signaling molecules suggesting their active involvement in not only physiological but also pathological molecular processes. The hyperlipidemic stress is a major risk factor of atherosclerosis, but its exact mechanisms of action at the membrane microdomains level remain elusive. The aim of the present study was to determine whether membrane-cytoskeleton proteome in the pulmonary tissue could be modulated by the hyperlipidemic stress, a major risk factor of atherosclerosis.

Results

High resolution mass spectrometry based proteomics analysis was performed for detergent resistant membrane microdomains isolated from lung homogenates of control, ApoE deficient and statin treated ApoE deficient

SUBMITTER: Suica VI 

PROVIDER: S-EPMC4666118 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature