Presence of the knockdown resistance mutation, Vgsc-1014F in Anopheles gambiae and An. arabiensis in western Kenya.

ABSTRACT:

Introduction

The voltage gated sodium channel mutation Vgsc-1014S (kdr-east) was first reported in Kenya in 2000 and has since been observed to occur at high frequencies in the local Anopheles gambiae s.s.

Population

The mutation Vgsc-1014F has never been reported from An. gambiae Complex complex mosquitoes in Kenya.

Findings

Molecularly confirmed An. gambiae s.s. (hereafter An. gambiae) and An. arabiensis collected from 4 different parts of western Kenya were genotyped for kdr from 2011 to 2013. Vgsc-1014F was observed to have emerged, apparently, simultaneously in both An. gambiae and An. arabiensis in 2012. A portion of the samples were submitted for sequencing in order to confirm the Vgsc-1014F genotyping results. The resulting sequence data were deposited in GenB

SUBMITTER: Ochomo E 

PROVIDER: S-EPMC4666190 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature