High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing's disease.

ABSTRACT:

Objective

To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing's disease.

Methods

In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a lesion. Firstly, two readers assessed both 1.5 T and 7.0 T MRI examinations unpaired in a random order for the presence of lesions. Consensus reading with a third neuroradiologist was used to define final lesions in all MRIs. Secondly, surgical outcome was evaluated. A comparison was made between the lesions visualized with MRI and the lesions found during surgery in 9/16 patients.

Results

The interobserver agreement for lesion detection was good at 1.5 T MRI (κ = 0.69) and 7.

SUBMITTER: de Rotte AA 

PROVIDER: S-EPMC4666272 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature