Functional Analysis of the Unique Cytochrome P450 of the Liver Fluke Opisthorchis felineus.

ABSTRACT: The basic metabolic cytochrome P450 (CYP) system is essential for biotransformation of sterols and xenobiotics including drugs, for synthesis and degradation of signaling molecules in all living organisms. Most eukaryotes including free-living flatworms have numerous paralogues of the CYP gene encoding heme monooxygenases with specific substrate range. Notably, by contrast, the parasitic flatworms have only one CYP gene. The role of this enzyme in the physiology and biochemistry of helminths is not known. The flukes and tapeworms are the etiologic agents of major neglected tropical diseases of humanity. Three helminth infections (Opisthorchis viverrini, Clonorchis sinensis and Schistosoma haematobium) are considered by the International Agency for Research on Cancer (IARC) as definite caus

SUBMITTER: Pakharukova MY 

PROVIDER: S-EPMC4666407 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature