Ranking of Reactions Based on Sensitivity of Protein Noise Depends on the Choice of Noise Measure.

ABSTRACT: Gene expression is a stochastic process. Identification of the step maximally affecting noise in the protein level is an important aspect of investigation of gene product distribution. There are numerous experimental and theoretical studies that seek to identify this important step. However, these studies have used two different measures of noise, viz. coefficient of variation and Fano factor, and have compared different processes leading to contradictory observations regarding the important step. In this study, we performed systematic global and local sensitivity analysis on two models of gene expression to investigate relative contribution of reaction rate parameters to steady state noise in the protein level using both the measures of noise. We analytically and computationally showed th

SUBMITTER: Gokhale S 

PROVIDER: S-EPMC4666593 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature