Do Longer Intervals between Challenges Reduce the Risk of Adverse Reactions in Oral Wheat Challenges?

ABSTRACT:

Background

The use of oral food challenges (OFCs) in clinics is limited because they are complicated and associated with anaphylactic symptoms. To increase their use, it is necessary to develop novel, effective, and safe methods. However, the effectiveness of different OFCs has not been compared.

Objective

To investigate the effect of ingestion methods on wheat allergy symptoms and treatment during OFCs.

Method

Without changing the total challenge dose, we changed the administration method from a 5-installment dose titration every 15 min (15-min interval method) to 3 installments every 30 min (30-min interval method). We retrospectively reviewed and compared the results of 65 positive 15-min interval wheat challenge tests conducted between July 2005 and February 2008

SUBMITTER: Yanagida N 

PROVIDER: S-EPMC4666606 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature