OrthoFind Facilitates the Discovery of Homologous and Orthologous Proteins.

ABSTRACT: Finding homologous and orthologous protein sequences is often the first step in evolutionary studies, annotation projects, and experiments of functional complementation. Despite all currently available computational tools, there is a requirement for easy-to-use tools that provide functional information. Here, a new web application called orthoFind is presented, which allows a quick search for homologous and orthologous proteins given one or more query sequences, allowing a recurrent and exhaustive search against reference proteomes, and being able to include user databases. It addresses the protein multidomain problem, searching for homologs with the same domain architecture, and gives a simple functional analysis of the results to help in the annotation process. orthoFind is easy to use a

SUBMITTER: Mier P 

PROVIDER: S-EPMC4666658 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature