Can CD44 Be a Mediator of Cell Destruction? The Challenge of Type 1 Diabetes.

ABSTRACT: CD44 is a multi-functional receptor with multiple of isoforms engaged in modulation of cell trafficking and transmission of apoptotic signals. We have previously shown that injection of anti-CD44 antibody into NOD mice induced resistance to type 1 diabetes (T1D). In this communication we describe our efforts to understand the mechanism underlying this effect. We found that CD44-deficient NOD mice develop stronger resistance to T1D than wild-type littermates. This effect is not explained by the involvement of CD44 in cell migration, because CD44-deficient inflammatory cells surprisingly had greater invasive potential than the corresponding wild type cells, probably owing to molecular redundancy. We have previously reported and we show here again that CD44 expression and hyaluronic acid (HA,

SUBMITTER: Assayag-Asherie N 

PROVIDER: S-EPMC4666674 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature