Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells.

ABSTRACT: Differentiation of functional thyroid epithelia from pluripotent stem cells (PSCs) holds the potential for application in regenerative medicine. However, progress toward this goal is hampered by incomplete understanding of the signaling pathways needed for directed differentiation without forced overexpression of exogenous transgenes. Here we use mouse PSCs to identify key conserved roles for BMP and FGF signaling in regulating thyroid lineage specification from foregut endoderm in mouse and Xenopus. Thyroid progenitors derived from mouse PSCs can be matured into thyroid follicular organoids that provide functional secretion of thyroid hormones in vivo and rescue hypothyroid mice after transplantation. Moreover, by stimulating the same pathways, we were also able to derive human thyroid pr

SUBMITTER: Kurmann AA 

PROVIDER: S-EPMC4666682 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature