Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data.

ABSTRACT:

Unlabelled

Chronic neuropathic pain, the most frequent condition affecting the peripheral nervous system, remains underdiagnosed and difficult to treat. Inhaled cannabis may alleviate chronic neuropathic pain. Our objective was to synthesize the evidence on the use of inhaled cannabis for chronic neuropathic pain. We performed a systematic review and a meta-analysis of individual patient data. We registered our protocol with PROSPERO CRD42011001182. We searched in Cochrane Central, PubMed, EMBASE, and AMED. We considered all randomized controlled trials investigating chronic painful neuropathy and comparing inhaled cannabis with placebo. We pooled treatment effects following a hierarchical random-effects Bayesian responder model for the population-averaged subject-specific effect.

SUBMITTER: Andreae MH 

PROVIDER: S-EPMC4666747 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature