Human papillomavirus genotype and oropharynx cancer survival in the United States of America.

ABSTRACT:

Background

The presence of human papillomavirus (HPV) DNA in oropharyngeal squamous cell cancer (OPSCC) tissue appears to be a strong predictor of improved prognosis, but this observation has not been explored in a population-based sample with generalisable findings.

Methods

Follow-up data from a large sample of OPSCC patients identified through six population-based cancer registries in the United States of America (USA) were used to characterise the association of tumour HPV status with survival.

Results

HPV DNA was detected in tumour tissue from 71% (378 in 529) of the OPSCC patients. A total of 65% of patients with HPV16-associated tumours survived 5 years compared to 46% of patients with other HPV types and 28% of patients with HPV-negative tumours (p log-rank tes

SUBMITTER: Goodman MT 

PROVIDER: S-EPMC4666760 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature