A high frequency of BRCA mutations in young black women with breast cancer residing in Florida.

ABSTRACT:

Background

Black women are disproportionately affected with triple-negative breast cancer and have relatively poor survival. To the authors' knowledge, it is not known to what extent differences in the clinical presentation of breast cancer between non-Hispanic white women and black women can be accounted for by the presence of mutations in the BRCA1 and BRCA2 genes. The authors sought to evaluate the frequency of BRCA pathogenic variants in a population-based sample of young black women with breast cancer.

Methods

Black women diagnosed with invasive breast cancer at age ≤50 years from 2009 to 2012 were recruited to the study through the Florida Cancer Registry. Participants underwent genetic counseling, completed a study questionnaire, and consented to release of their medi

SUBMITTER: Pal T 

PROVIDER: S-EPMC4666784 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature