Gender-specific effects of intrauterine growth restriction on the adipose tissue of adult rats: a proteomic approach.

ABSTRACT:

Background

Intrauterine growth restriction (IUGR) may program metabolic alterations affecting physiological functions and lead to diseases in later life. The adipose tissue is an important organ influencing energy homeostasis. The present study was aimed at exploring the consequences of IUGR on the retroperitoneal adipose tissue of adult male and female rats, using a proteomic approach.

Methods and results

Pregnant Wistar rats were fed with balanced chow, either ad libitum (control group) or restricted to 50 % of control intake (restricted group) during the whole gestation. The offspring were weaned to ad libitum chow and studied at 4 months of age. Retroperitoneal fat was analyzed by two-dimensional gel electrophoresis followed by mass spectrometry. Both male and female res

SUBMITTER: de Souza AP 

PROVIDER: S-EPMC4667418 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature