Hsp90 and hepatobiliary transformation during sea lamprey metamorphosis.

ABSTRACT:

Background

Biliary atresia (BA) is a human infant disease with inflammatory fibrous obstructions in the bile ducts and is the most common cause for pediatric liver transplantation. In contrast, the sea lamprey undergoes developmental BA with transient cholestasis and fibrosis during metamorphosis, but emerges as a fecund adult. Therefore, sea lamprey liver metamorphosis may serve as an etiological model for human BA and provide pivotal information for hepatobiliary transformation and possible therapeutics.

Results

We hypothesized that liver metamorphosis in sea lamprey is due to transcriptional reprogramming that dictates cellular remodeling during metamorphosis. We determined global gene expressions in liver at several metamorphic landmark stages by integrating mRNA-Seq and

SUBMITTER: Chung-Davidson YW 

PROVIDER: S-EPMC4667476 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature