Induction of neural differentiation in rat C6 glioma cells with taxol.

ABSTRACT:

Background

Glioblastoma is a common and aggressive type of primary brain tumor. Several anticancer drugs affect GBM (glioblastoma multiforme) cells on cell growth and morphology. Taxol is one of the widely used antineoplastic drugs against many types of solid tumors, such as breast, ovarian, and prostate cancers. However, the effect of taxol on GBM cells remains unclear and requires further investigation.

Methods

Survival rate of C6 glioma cells under different taxol concentrations was quantified. To clarify the differentiation patterns of rat C6 glioma cells under taxol challenge, survived glioma cells were characterized by immunocytochemical, molecular biological, and cell biological approaches.

Results

After taxol treatment, not only cell death but also morphologic

SUBMITTER: Chao CC 

PROVIDER: S-EPMC4667627 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature