Genistein alleviates pressure overload-induced cardiac dysfunction and interstitial fibrosis in mice.

ABSTRACT:

Background and purpose

Pressure overload-induced cardiac interstitial fibrosis is viewed as a major cause of heart failure in patients with hypertension or aorta atherosclerosis. The purpose of this study was to investigate the effects and the underlying mechanisms of genistein, a natural phytoestrogen found in soy bean extract, on pressure overload-induced cardiac fibrosis.

Experimental approach

Genisten was administered to mice with pressure overload induced by transverse aortic constriction. Eight weeks later, its effects on cardiac dysfunction, hypertrophy and fibrosis were determined. Its effects on proliferation, collagen production and myofibroblast transformation of cardiac fibroblasts (CFs) and the signalling pathways were also assessed in vitro.

Key results

SUBMITTER: Qin W 

PROVIDER: S-EPMC4667871 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature