Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina.

ABSTRACT: Vascular development and maintenance are controlled by a complex transcriptional program, which integrates both extracellular and intracellular signals in endothelial cells. Here we study the roles of three closely related SoxF family transcription factors-Sox7, Sox17, and Sox18 -in the developing and mature mouse vasculature using targeted gene deletion on a mixed C57/129/CD1 genetic background. In the retinal vasculature, each SoxF gene exhibits a distinctive pattern of expression in different classes of blood vessels. On a mixed genetic background, vascular endothelial-specific deletion of individual SoxF genes has little or no effect on vascular architecture or differentiation, a result that can be explained by overlapping function and by reciprocal regulation of gene expression betwee

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC4667919 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature