Ethnic differences in hepatic and systemic insulin sensitivity and their associated determinants in obese black and white South African women.

ABSTRACT:

Aims/hypothesis

There is evidence to suggest that ectopic fat deposition in liver and skeletal muscle may differ between black and white women resulting in organ-specific differences in insulin sensitivity. Accordingly, the aim of the study was to examine ethnic differences in hepatic and peripheral insulin sensitivity, and the association with hepatic and skeletal muscle lipid content, and skeletal muscle gene expression.

Methods

In a cross-sectional study including 30 obese premenopausal black and white women, body composition (dual energy x-ray absorptiometry), liver fat and skeletal muscle (soleus and tibialis anterior) fat accumulation (proton-magnetic resonance spectroscopy), skeletal muscle gene expression, insulin sensitivity (two-step isotope labelled, hyperinsulina

SUBMITTER: Goedecke JH 

PROVIDER: S-EPMC4668114 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature