In vivo endomicroscopy improves detection of Barrett's esophagus-related neoplasia: a multicenter international randomized controlled trial (with video).

ABSTRACT:

Background

Confocal laser endomicroscopy (CLE) enables in vivo microscopic imaging of the GI tract mucosa. However, there are limited data on endoscope-based CLE (eCLE) for imaging Barrett's esophagus (BE).

Objective

To compare high-definition white-light endoscopy (HDWLE) alone with random biopsy (RB) and HDWLE + eCLE and targeted biopsy (TB) for diagnosis of BE neoplasia.

Design

Multicenter, randomized, controlled trial.

Setting

Academic medical centers.

Patients

Adult patients with BE undergoing routine surveillance or referred for early neoplasia.

Intervention

Patients were randomized to HDWLE + RB (group 1) or HDWLE + eCLE + TB (group 2). Real-time diagnoses and management plans were recorded after HDWLE in both groups and after eCLE in group

SUBMITTER: Canto MI 

PROVIDER: S-EPMC4668117 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature