Increased high-density lipoprotein cholesterol levels in mice with XX versus XY sex chromosomes.

ABSTRACT:

Objective

The molecular mechanisms underlying sex differences in dyslipidemia are poorly understood. We aimed to distinguish genetic and hormonal regulators of sex differences in plasma lipid levels.

Approach and results

We assessed the role of gonadal hormones and sex chromosome complement on lipid levels using the four core genotypes mouse model (XX females, XX males, XY females, and XY males). In gonadally intact mice fed a chow diet, lipid levels were influenced by both male-female gonadal sex and XX-XY chromosome complement. Gonadectomy of adult mice revealed that the male-female differences are dependent on acute effects of gonadal hormones. In both intact and gonadectomized animals, XX mice had higher HDL cholesterol (HDL-C) levels than XY mice, regardless of male-fem

SUBMITTER: Link JC 

PROVIDER: S-EPMC4668127 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature