Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway.

ABSTRACT:

Purpose

Cervical cancer is one of the most common causes of cancer mortality for women living in poverty, causing more than 28,000 deaths annually in Latin America and 266,000 worldwide. To better understand the molecular basis of the disease, we ascertained blood and tumor samples from Guatemala and Venezuela and performed genomic characterization.

Experimental design

We performed human papillomavirus (HPV) typing and identified somatically mutated genes using exome and ultra-deep targeted sequencing with confirmation in samples from Mexico. Copy number changes were also assessed in the exome sequence.

Results

Cervical cancer cases in Guatemala and Venezuela have an average age of diagnosis of 50 years and 5.6 children. Analysis of 675 tumors revealed activation of P

SUBMITTER: Lou H 

PROVIDER: S-EPMC4668220 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature